New Study Shows Immune Imprinting Effects of mRNA Vaccination: Potential Risks of Antibody Dependent Enhancement (ADE)
Immune Memory, Variant Specificity, and ADE Concerns in COVID-19 Vaccination
Recent research conducted by the University of Washington has shed light on the concept of immune imprinting among individuals who have received multiple doses of the original COVID-19 mRNA vaccine.
The study found that those who had taken at least three doses of the initial vaccine exhibited strong immune imprinting, leading to a unique response when subsequently vaccinated with the latest XBB.1.5 mRNA boosters.
Immune imprinting occurs when prior exposures create a robust immune memory, causing the body to produce antibodies targeting past experiences even when faced with new variants or vaccines.
The study revealed that individuals who had received multiple Wuhan-variant mRNA vaccinations produced antibodies primarily targeting the original COVID-19 strain rather than the XBB.1.5 variant. Despite some participants developing immune cells specific to XBB.1.5, a significant proportion showed a limited to no antibody response against this new variant. Furthermore, the antibodies generated post-XBB.1.5 vaccination demonstrated cross-reactivity against different variants, including XBB.1.5, but lacked specificity towards the latter.
“Imprinting is not a new concept, but the situation we are looking at seems to be quite unique,” said David Veesler, professor and chair in the Department of Biochemistry at UW, in the press release.
The researchers highlighted two possible reasons for this phenomenon. First, residents in Seattle, where most samples were collected, may have been exposed to the virus numerous times through vaccinations and infections, leading to the development of antibodies and immune memory cells more attuned to the original virus.
Second, mRNA vaccines like the COVID-19 vaccines might induce a stronger immune imprinting effect compared to traditional vaccines, potentially resulting in a heightened immune response favoring the original strain.
Antibody Dependent Enhancement (ADE) and Dengue Fever
Antibody-dependent enhancement (ADE) is a phenomenon where pre-existing non-neutralizing antibodies facilitate viral entry into host cells, potentially worsening disease outcomes. ADE has been observed in diseases like dengue fever, where antibodies from a previous infection can enhance the uptake of a different dengue virus serotype, leading to severe manifestations such as hemorrhagic fever.
Analysis of Immune Imprinting and ADE Risk with mRNA Vaccination
In light of the findings on immune imprinting among individuals receiving multiple COVID-19 mRNA vaccinations, there is a speculative concern regarding the potential risk of ADE with mRNA vaccination. The strong immune imprinting observed in response to the original vaccine and subsequent boosters raises questions about whether this could inadvertently enhance the entry or replication of new variants, similar to ADE mechanisms seen in other viral infections like dengue fever.
Further research and monitoring are essential to assess any potential risks of ADE associated with immune imprinting from mRNA vaccination. Understanding the dynamics of immune response and antibody specificity towards different variants is crucial in optimizing vaccination strategies and ensuring long-term efficacy and safety in combating evolving viruses like COVID-19.
217 guy probably doesn't even exist..... let's put a "mask" on this and move on..... lol! ☠💉😷🤡😂
...oh, for for some real biology, listen to JJ Couey.... he is the real deal.....not some bot.....
https://www.twitch.tv/gigaohmbiological
https://gigaohmbiological.substack.com/
No it's not. There is a robust immune response still (even with this man with 217 vaccinations). They ARE producing antibodies to new variants:
https://www.medrxiv.org/content/10.1101/2023.12.12.23299855v1.full
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00746-6/fulltext
Feel free to continue with your pet theories on dudstack--it's where all the garbage goes. But can we PLEASE bet some bitcoin on your pet theory??? I would LOVE to make some easy money here:
https://www.science.org/content/blog-post/antibody-dependent-enhancement-and-coronavirus-vaccines
https://www.sciencedirect.com/science/article/pii/S1201971220307311